Istiklol were crowned TFF Cup champions for a sixth time in the 2021 edition.
Final
Khatlon 0-1 Istiklol
(Alexey Larin 90 + 4)
Third-place play-off
Ravshan 1-2 Regar-TadAZ
(Murodov 86, Ganiev 24 53)
Semi-finals
Istiklol 3-2 Regar-TadAZ
(M. Dzhalilov 56, Ashurmamadov 77, Juraboev 82; Makhamadiev 5, Ganiev 26)
Khatlon 2-0 Ravshan
(Gaten 33, 90+2)
Preliminary round

CSKA 0-2 Istiklol
Ravshan 5-2 Mastchoh
Barkchi 0-5 Khatlo
Istiklol 6-1 Mastchoh
CSKA 1-2 Ravshan
Regar-TadAZ 0-1 Khatlon

Ravshan 0-4 Istiklol
Mastchoh 2-3 CSKA
Barkchi 1-2 Regar-TadAZ
What happened in 2020?
Ravshan clinched their second title beating Khatlon 1-0 in the Dushanbe final. En route to the showpiece, the second-tier outfit overcame Istiklol 4-2 in the quarter-finals, before edging past Regar-TadAZ 1-0 in the semis.